早期在低能量震波治療文獻中的討論,LIEST主要都是針對血管性的勃起功能障礙,經過根除性攝護腺手術的病人及骨盆腔手術後的病人通常被排除在外,所以較少臨床的數據,僅有2015年Chung等學者的研究中,有3名診斷是血管性勃起功能障礙的根除性攝護腺切除術後患者,有不錯的預後[16]。直到2016年,Li等學者的基礎研究,LIEST對於骨盆腔神經損傷的大鼠在低能量震波治療後可以造成陰莖組織中的nNOS positive神經再生[18]。更進一步的,Frey等學者的臨床研究,指出有做過雙側神經保留手術的根除攝護腺切除手術的病人在低能量震波治療後,可以改善勃起功能[19]。以新光醫院的經驗,目前統計有八位有接受過至少一側神經保留手術的攝護腺切除手術後病人,進行6個LIEST療程治療及12次療程之後,勃起硬度分數(erectile hardness score, EHS)和國際勃起功能指數(international index of erectile function-5, IIEF-5)皆可以增加,亦有超過一半的改善率。因此,儘管局部血管和神經組織在根除性攝護腺切除術合併神經保留手術後可能受到影響,但是在術後勃起功能障礙的患者,LIEST仍然是可以選擇的治療方式之一。
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